Testing the Antidepressant Activity of Fennel (Foeniculum vulgare Mill) In Vitro Using the Forced Swimming Test (FST) Method

Raisya Hasina S.; Siti Rahmatul Aini; Khairil Pahmi

doi:10.51673/jikf.v12i1.2248

Raisya Hasina S. Faculty of Medicine and Health Science, The University of Mataram
Siti Rahmatul Aini Faculty of Medicine and Health Science, The University of Mataram
Khairil Pahmi Faculty of Medicine and Health Science, The University of Mataram

DOI: https://doi.org/10.51673/jikf.v12i1.2248

Keywords: Antidepressan, Fennel, Extract

Abstract

Antidepressants are a therapy used for depression sufferers with the aim of reducing symptoms, minimizing side effects and returning them to their original condition. Treatment of depression requires safe and effective therapy to prevent severity. Currently, there are many plants that have potential as antidepressants, such as fennel. The method that can be used to evaluate the effect of antidepressants is the forced swimming test (FST). 24 mice were divided into 8 groups and each group was treated with amitriptyline as a positive control, Na-CMC 0.5% as negative control and fennel infusion as test sample. The data obtained consisted of duration of immobility, climbing, and swimming which was then analyzed using SPSS with the one-way ANOVA test. The results of one-way ANOVA test for immobility, climbing, and swimming time showed that sig. values sequencely are 0.03, 0.006, and 0.016 (P< 0.05). It means that immobility, climbing, and swimming time have significant differences between group of control and treatment.

References

Alvarado-García PAA, Soto-Vásquez MR, Rosales-Cerquin LE, RodrigoVillanueva EM, Jara-Aguilar DR, Tuesta-Collantes L, 2022, Anxiolytic and Antidepressant-like Effects Phcogj.com of Foeniculum vulgare Essential Oil. Pharmacogn J.;12(1): 425-431.
Aubin, Henri-Jean, 2002, Tolerability and Safety of Sustained-Release Bupropion in the Management of Smoking Cessation. Drugs ; 62: 45–52.
Csoka, Antonei; Bahrick, Audrey; Mehtonen, Olli-Pekka, 2007, Persistent Sexual Dysfunction after Discontinuation of Selective Serotonin Reuptake Inhibitors. Journal of Sexual Medicine, 5 (1): 227–33.
Chouinard, G; Steiner, W., 1986, A case of mania induced by high-dose fluoxetine treatment. The American Journal of Psychiatry, 143 (5): 686.
Ghazanfarpour M, Mohammadzadeh F, Shokrollahi P, Khadivzadeh T, Najaf Najafi M, Hajirezaee H, Afiat M., 2018, Effect of Foeniculum vulgare (fennel) on symptoms of depression and anxiety in postmenopausal women: a double-blind randomised controlled trial. J Obstet Gynaecol. Jan;38(1):121-126.
Gold PW, Goodwin FK, Chrousus GP., 1988, Clinical and biochemical manifestations of depression in relation to the neurobiology of stress: Part 1. N Engl J Med;319:348– 53.
Singh, J.N., Sunil, K., Rana A.C., 2013, Antidepressant Activity of Methanolic Extract of Foeniculum Vulgare (Fennel) Fruits in Experimental Animal Models. J App Pharm Sci; 3 (09): 065-070.
MacKay, FJ; Dunn, NR; Wilton, LV; Pearce, GL; Freemantle, SN; Mann, RD., 1997, A comparison of fluvoxamine, fluoxetine, sertraline and paroxetine examined by observational cohort studies. Pharmacoepidemiology and drug safety; 6 (4): 235–246.
Ramadhan, M.A., Rini, G.H., Azhahra, R.D., Zahra N., Raissa, T.H., , Meizora, B.C., Hidayat, L.H., 2023, Uji Efektivitas Antidepresan Obat Herbal Kapsul Ekstrak Daun Pegagan (Centella Asiatica L.) Pada Mencit Dengan Metode Forced Swimming Test, Bio Sains: Jurnal Ilmiah Biologi, Volume 3, Nomer 1, Agustus 2023.
Maleki, S.A., Maleki, S.G., 2021, Antidepressant-like effects of Foeniculum vulgare essential oil and potential involvement of dopaminergic and serotonergic systems on mice in the forced swim test, PharmaNutrition, Volume 15.
Settle EC, Settle GP., 1984, A case of mania associated with fluoxetine. The American Journal of Psychiatry,; 141(2): 280–281.
The World Health Report, 2001, Mental health: new understanding new hope. WHO, Geneva.
WHO, 1998, Mental and Neurological Disorders. Fact sheet No.25.
World Health Organization, 2002, Gender Disparities in Mental Health.